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Sulfuric acid is A strong acid is one that is 100 percent ionized in a solution, and a weak acid is on Live a Healthy Lifestyle! Subscribe to our free newsletters to receive latest health news and alerts to your email inbox. Okadaic acid. Apoptosis Inducer & Phosphatase Inhibitor; induces apoptosis e.g. in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Buy Okadaic Acid Sodium Salt - an affordable, high quality PP1 Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide. Okadaic Acid is one of the toxins associated with diarrheic shellfish poisoning ( DSP).

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 Okadaic Acid mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC. Summary: PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes.

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Ibelings BW, Chorus I. Accumulation of DSP have their origin in okada acid or are for example dinophysistoxin and T., Maynes, Kathy S., et al., Crystal structure of the tumorpromoter okadaic acid. av O Lindahl · Citerat av 6 — variation of Okadaic acid content in farmed mussels, Mytilus edulis Linnaeus, 1758, along the Swedish west coast. J. Shellfish Res. 9, 103-108. Kollberg S. and Okadaic acid (OA), som aktiverar MST2, underlättar den komplexa bildningen av MOB1, MST2 och NDR1 i HEK293FT-celler.

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Okadaic Acid, Free Acid, >98%, CAS#78111-17-8, More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels). Okadaic Acid: Equivalent Term Ocadaic Acid: CAS Registry Number 78111-17-8 Definition : A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING. Structure : Top Interacting Genes Okadaic Acid, Free Acid, >98%, CAS#78111-17-8, More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels). This work describes the selection and identification of DNA aptamers that bind with high affinity and specificity to okadaic acid (OA), a lipophilic marine biotoxin that accumulates in shellfish.

Protein phosphatase 1 and 2A inhibitor. Cited in 28 publications. Description. Okadaic acid is a diarrhetic shellfish toxin initially produced by dinoflagellates and sea sponges; it exhibits neurotoxic and anticancer activities.
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CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = 0.1 nM).

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport. Okadaic acid is a toxin that is known for causing diarrhetic shellfish poisoning.
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Profiles and levels of fatty acid esters of okadaic acid group toxins

DOI: 10.1074. However toxins produced by phytoplankton are accumulated by mussels and oysters and may result in poisoning when consumed. Okadaic acid is the toxin that Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Lett.